Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation.

ABSTRACT:

Background

Depending on their distinct properties, titanium dioxide nanoparticles (TiO₂-NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release and public concerns. In sunscreen formulations, supplementation of TiO₂-NPs may reach up to 25% (w/w). Ocular contact with TiO₂-NPs may occur accidentally in certain cases, allowing undesirable risks to human vision. This study aimed to understand the barrier integrity of retinal endothelial cells in response to TiO₂-NP exposure. bEnd.3 cells and human retinal endothelial cells (HRECs) were exposed to TiO₂-NP, followed by examination of their tight junction components and functions.

Results

TiO2-NP treatment apparently ind

SUBMITTER: Chan YJ 

PROVIDER: S-EPMC7796566 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature