Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19.

ABSTRACT:

Background

Genetic variation at a multigene cluster at chromosome 3p21.31 and the ABO blood group have been associated with the risk of developing severe COVID-19, but the mechanism remains unclear. Complement activation has been associated with COVID-19 severity.

Objective

The aim of this study was to examine whether chromosome 3p21.31 and the ABO variants are linked to the activation of the complement cascade in COVID-19 patients.

Methods

We considered 72 unrelated European hospitalized patients with genetic data and evaluation of circulating C5a and soluble terminal complement complex C5b-9 (SC5b-9). Twenty-six (36.1%) patients carried the rs11385942 G>GA variant and 44 (66.1%) non-O blood group associated with increased risk of severe COVID-19.

Results

C5a

SUBMITTER: Valenti L 

PROVIDER: S-EPMC7796659 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature