White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood.

ABSTRACT:

Background

Prevention of suicide in individuals with early-onset bipolar disorder (BD) remains a challenge. Diffusion magnetic resonance imaging studies in BD have identified neural correlates of emotional dysregulation implicated in BD and suicide. Using diffusion magnetic resonance imaging, we sought to identify neural signatures of suicide attempts in adults with childhood-onset BD who have been clinically followed for up to 19 years as part of the COBY (Course and Outcome of Bipolar Youth) study.

Methods

Diffusion magnetic resonance imaging data were collected in 68 adults with BD: 20 in the suicide attempter (SA⁺) group and 48 in the non-suicide attempter (SA^-) group. Multivariate analysis of covariance was used to identify the effect of group (SA<

SUBMITTER: Lima Santos JP 

PROVIDER: S-EPMC7796908 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature