Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics.

ABSTRACT:

Introduction

Current evidence supports a vital role of the microbiota on health outcomes, with alterations in an otherwise healthy balance linked to chronic medical conditions like celiac disease (CD). Recent advances in microbiome analysis allow for unparalleled profiling of the microbes and metabolites. With the growing volume of data available, trends are emerging that support a role for the gut microbiota in CD pathogenesis.

Areas covered

In this article, the authors review the relationship between factors such as genes and antibiotic exposure on CD onset and the intestinal microbiota. The authors also review other microbiota within the human body (like the oropharynx) that may play a role in CD pathogenesis. Finally, the authors discuss implications for disease modifica

SUBMITTER: Olshan KL 

PROVIDER: S-EPMC7796936 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature