Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1⁺ prostate luminal cells.

ABSTRACT: Prostate adenocarcinoma undergoes neuroendocrine differentiation to acquire resistance toward antihormonal therapies. The underlying mechanisms have been investigated extensively, among which Sox2 has been shown to play a critical role. However, genetic evidence in mouse models for prostate cancer to support the crucial role of Sox2 is missing. The adult mouse prostate luminal cells contain both castration-resistant Sox2-expressing Sca-1⁺ cells and castration-responsive Sca-1^- cells. We show that both types of the luminal cell are susceptible to oncogenic transformation induced by loss of function of the tumor suppressor Pten. The tumors derived from the Sca-1⁺ cells are castration resistant and are more inclined to develop castration-induced neuroendocrine

SUBMITTER: Kwon OJ 

PROVIDER: S-EPMC7796948 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature