Effect of the silica nanoparticle size on the osteoinduction of biomineralized silk-silica nanocomposites.

ABSTRACT: Understanding the properties and behavior of biomineralized protein-based materials at the organic-inorganic interface is critical to optimize the performance of such materials for biomedical applications. To that end, this work investigates biomineralized protein-based films with applications for bone regeneration. These films were generated using a chimeric protein fusing the consensus repeat derived from the spider Nephila clavipes major ampullate dragline silk with the silica-promoting peptide R5 derived from the Cylindrotheca fusiformis silaffin gene. The effect of pH on the size of silica nanoparticles during their biomineralization on silk films was investigated, as well as the potential impact of nanoparticle size on the differentiation of human mesenchymal stem cells (hMSCs) into

SUBMITTER: Martin-Moldes Z 

PROVIDER: S-EPMC7796966 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature