Global electrical heterogeneity associated with drug-induced torsades de pointes.

ABSTRACT:

Background

Drugs belonging to diverse therapeutic classes can prolong myocardial refractoriness or slow conduction. These drugs may be effective and well-tolerated, but the risk of sudden cardiac death from torsades de pointes (TdP) remains a major concern. The corrected QT interval has significant limitations when used for risk stratification. Measurement of global electrical heterogeneity (GEH) could help identify the substrate vulnerable to drug-induced ventricular arrhythmias.

Objective

The purpose of this study was to improve risk stratification for drug-induced TdP by measuring GEH on the electrocardiogram (ECG).

Methods

We analyzed ECG data from a case-control study of patients with a history of drug-induced TdP as well as age- and sex-matched controls. Vectorc

SUBMITTER: Stabenau HF 

PROVIDER: S-EPMC7796973 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature