Sex-specific I_KAS activation in rabbit ventricles with drug-induced QT prolongation.

ABSTRACT:

Background

Female sex is a known risk factor for drug-induced long QT syndrome (diLQTS). We recently demonstrated a sex difference in apamin-sensitive small-conductance Ca²⁺-activated K⁺ current (I_KAS) activation during β-adrenergic stimulation.

Objective

The purpose of this study was to test the hypothesis that there is a sex difference in I_KAS in the rabbit models of diLQTS.

Methods

We evaluated the sex difference in ventricular repolarization in 15 male and 22 female Langendorff-perfused rabbit hearts with optical mapping techniques during atrial pacing. HMR1556 (slowly activating delayed rectifier K⁺ current [I_Ks] blocker), E4031 (rapidly activating delayed rectifier K⁺ current [I_Kr<

SUBMITTER: Wu AZ 

PROVIDER: S-EPMC7796981 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature