Characterization of adipogenic, PPARγ, and TRβ activities in house dust extracts and their associations with organic contaminants.

ABSTRACT: In this study, we sought to expand our previous research on associations between bioactivities in dust and associated organic contaminants. Dust samples were collected from central NC homes (n = 188), solvent extracted, and split into two fractions, one for analysis using three different bioassays (nuclear receptor activation/inhibition and adipocyte development) and one for mass spectrometry (targeted measurement of 124 organic contaminants, including flame retardants, polychlorinated biphenyls, perfluoroalkyl substances, pesticides, phthalates, and polycyclic aromatic hydrocarbons). Approximately 80% of dust extracts exhibited significant adipogenic activity at concentrations that are comparable to estimated exposure for children and adults (e.g. ~20 μg/well dust) via either triglyceride

SUBMITTER: Kassotis CD 

PROVIDER: S-EPMC7796983 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature