Spatially Targeted Proteomics of the Host-Pathogen Interface during Staphylococcal Abscess Formation.

ABSTRACT: Staphylococcus aureus is a common cause of invasive and life-threatening infections that are often multidrug resistant. To develop novel treatment approaches, a detailed understanding of the complex host-pathogen interactions during infection is essential. This is particularly true for the molecular processes that govern the formation of tissue abscesses, as these heterogeneous structures are important contributors to staphylococcal pathogenicity. To fully characterize the developmental process leading to mature abscesses, temporal and spatial analytical approaches are required. Spatially targeted proteomic technologies such as micro-liquid extraction surface analysis offer insight into complex biological systems including detection of bacterial proteins and their abundance in the h

SUBMITTER: Guiberson ER 

PROVIDER: S-EPMC7796985 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature