A network-based comparative framework to study conservation and divergence of proteomes in plant phylogenies.

ABSTRACT: Comparative functional genomics offers a powerful approach to study species evolution. To date, the majority of these studies have focused on the transcriptome in mammalian and yeast phylogenies. Here, we present a novel multi-species proteomic dataset and a computational pipeline to systematically compare the protein levels across multiple plant species. Globally we find that protein levels diverge according to phylogenetic distance but is more constrained than the mRNA level. Module-level comparative analysis of groups of proteins shows that proteins that are more highly expressed tend to be more conserved. To interpret the evolutionary patterns of conservation and divergence, we develop a novel network-based integrative analysis pipeline that combines publicly available transcriptomic d

SUBMITTER: Shin J 

PROVIDER: S-EPMC7797074 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature