Transplanted embryonic retinal stem cells have the potential to repair the injured retina in mice.

ABSTRACT:

Background

Stem cell transplantation has been reported as one of the promising strategies to treat retinal degenerative diseases. But, the application and the role of retina stem cells (RSCs) in the treatment of patients with retinal degenerative diseases have not been fully revealed. This study aimed to investigate the potential role of transplantation of the embryo-derived RSCs into the vitreous cavity in repairing the damaged retina in mice.

Methods

RSCs were isolated from Kunming mice E17 embryonic retina and ciliary body tissues, and labeled with 5-bromo-2'-deoxyuridin (BrdU). Retinal optic nerve crush injury was induced in left eyes in male Kunming mice by ring clamping the optic nerve. The 6th -generation of BrdU-labeled RSCs were transplanted into the damaged retina

SUBMITTER: Feng X 

PROVIDER: S-EPMC7797095 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature