Re-purposing software for functional characterization of the microbiome.

ABSTRACT:

Background

Widespread bioinformatic resource development generates a constantly evolving and abundant landscape of workflows and software. For analysis of the microbiome, workflows typically begin with taxonomic classification of the microorganisms that are present in a given environment. Additional investigation is then required to uncover the functionality of the microbial community, in order to characterize its currently or potentially active biological processes. Such functional analysis of metagenomic data can be computationally demanding for high-throughput sequencing experiments. Instead, we can directly compare sequencing reads to a functionally annotated database. However, since reads frequently match multiple sequences equally well, analyses benefit from a hierarchical an

SUBMITTER: Gardiner LJ 

PROVIDER: S-EPMC7797099 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature