Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season.

ABSTRACT:

Background

Transmission stemming from asymptomatic infections is increasingly being recognized as a threat to malaria elimination. In many regions, malaria transmission is seasonal. It is not well understood whether Plasmodium falciparum modulates its investment in transmission to coincide with seasonal vector abundance.

Methods

We sampled 1116 asymptomatic individuals in the wet season, when vectors are abundant, and 1743 in the dry season, in two sites in western Kenya, representing different transmission intensities (Chulaimbo, moderate transmission, and Homa Bay, low transmission). Blood samples were screened for P. falciparum by qPCR, and gametocytes by pfs25 RT-qPCR.

Results

Parasite prevalence by qPCR was 27.1% (Chulaimbo, dry), 48.2% (Chulaimbo, wet), 9.4% (Ho

SUBMITTER: Oduma CO 

PROVIDER: S-EPMC7797145 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature