HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.

ABSTRACT:

Background

The number of strategies to prevent HIV transmission has increased following trials evaluating antiretroviral therapy (ART), preexposure prophylaxis (PrEP) and male circumcision. Serodiscordant couples need guidance on the effects of these strategies alone, and in combination with each other, on HIV transmission.

Methods

We estimated the sexual risk of HIV transmission over 1-year and 10-year periods among male-male and male-female serodiscordant couples. We assumed the following reductions in transmission: 80% from consistent condom use; 54% from circumcision in the negative male partner of a heterosexual couple; 73% from circumcision in the negative partner of a male-male couple; 71% from PrEP in heterosexual couples; 44% from PrEP in male-male couples; and 96%

SUBMITTER: Lasry A 

PROVIDER: S-EPMC7797164 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature