Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.

ABSTRACT: Covering: 2014-2019We review recent progress on natural products that target cytoskeletal components, including microtubules, actin, intermediate filaments, and septins and highlight their demonstrated and potential utility in the treatment of human disease. The anticancer efficacy of microtubule targeted agents identified from plants, microbes, and marine organisms is well documented. We highlight new microtubule targeted agents currently in clinical evaluations for the treatment of drug resistant cancers and the accumulating evidence that the anticancer efficacy of these agents is not solely due to their antimitotic effects. Indeed, the effects of microtubule targeted agents on interphase microtubules are leading to their potential for more mechanistically guided use in cancers as well a

SUBMITTER: Risinger AL 

PROVIDER: S-EPMC7797185 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature