Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension.

ABSTRACT:

Aims

Salt-sensitive (SS) hypertension is accompanied by impaired vasodilation in the systemic and renal circulation. However, the causal relationship between vascular dysfunction and salt-induced hypertension remains controversial. We sought to determine whether primary vascular dysfunction, characterized by a failure to vasodilate during salt loading, plays a causal role in the pathogenesis of SS hypertension.

Methods and results

Mice selectively expressing a peroxisome proliferator-activated receptor γ dominant-negative mutation in vascular smooth muscle (S-P467L) exhibited progressive SS hypertension during a 4 week high salt diet (HSD). This was associated with severely impaired vasodilation in systemic and renal vessels. Salt-induced impairment of vasodilation occurred

SUBMITTER: Wu J 

PROVIDER: S-EPMC7797211 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature