Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling.

ABSTRACT:

Aims

Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of cardiomyocytes and delays cellular senescence by maintaining telomere length, but the mechanism remains unknown. Another pathway responsible for regulating telomere length is the transforming growth factor beta (TGFβ) signalling pathway where inhibiting TGFβ signalling maintains telomere length. The relationship between Pim1 and TGFβ has not been explored. This study delineates the mechanism of telomere length regulation by the interplay between Pim1 and components of TGFβ signalling pathways in proliferating A549 cells and post-mitotic cardiomyocy

SUBMITTER: Ebeid DE 

PROVIDER: S-EPMC7797214 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature