ADAM10 promotes the proliferation of ligamentum flavum cells by activating the PI3K/AKT pathway.

ABSTRACT: Ligamentum flavum hypertrophy (LFH) is an important cause of spinal canal stenosis and posterior longitudinal ligament ossification. Although a number of studies have focused on the mechanisms responsible for LFH, the cellular mechanisms remain poorly understood. The aim of the present study was to investigate the roles of differentially expressed genes (DEGs) in LFH, elucidate the mechanisms responsible for LFH and provide a potential therapeutic target for further studies. The GSE113212 dataset was downloaded from the Gene Expression Omnibus (GEO) database. The microarray data were analyzed and DEGs were obtained. Bioinformatics methods, such as Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and protein‑protein interaction (PPI) network analyses were used t

SUBMITTER: Pan B 

PROVIDER: S-EPMC7797459 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature