Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes.

ABSTRACT:

Background

Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate inflammation, but its role in COVID-19 is unknown.

Methods

A prospective, longitudinal, single center study was performed in hospitalized patients with COVID-19. Plasma concentrations of complement factors C3a, C3c, and terminal complement complex (TCC) were assessed at baseline and during hospital admission. In parallel, routine laboratory and clinical parameters were collected from medical files and analyzed.

Results

Complement factors C3a, C3c, and TCC were significantly increased in plasma of patients with CO

SUBMITTER: de Nooijer AH 

PROVIDER: S-EPMC7797765 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature