Comparison of PD-L1 immunohistochemical assays and the significance of PD-L1 expression in thymoma.

ABSTRACT: Thymoma is a relatively rare malignancy, which is categorized as thymic epithelial tumor but known as the most common pathology that is developed in the anterior mediastinum. Complete resection is recommended for localized tumors and usually favorable prognosis can be obtained. However, poor survival period has been reported in unresectable cases exhibiting extensive invasion or distant metastasis, as effective chemotherapeutic regimens are restrained. We previously assessed expression of programmed death ligand 1 (PD-L1) and programmed death 1 (PD-1) and discussed their prospective application in the immunotherapy of thymic epithelial tumors. After our publication, additional studies using reliable PD-L1 antibodies, which are currently administered to predict efficacy of PD-1/PD-L1 blocka

SUBMITTER: Yokoyama S 

PROVIDER: S-EPMC7797863 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature