Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis.

ABSTRACT:

Objectives

The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological responses to cold stress or sensation of ambient temperatures. We previously found that loss of acyl-CoA-binding protein (ACBP) in keratinocytes upregulates lipolysis in white adipose tissue and alters hepatic lipid metabolism, suggesting a link between epidermal barrier functions and systemic energy metabolism.

Methods

To assess the physiological responses to loss of ACBP in keratinocytes in detail, we used full-body ACBP^-/- and skin-specific ACBP^-/- knockout mice to clarify how loss of ACBP affects 1) energy exp

SUBMITTER: Neess D 

PROVIDER: S-EPMC7797911 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature