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Localization and function of a Plasmodium falciparum protein (PF3D7_1459400) during erythrocyte invasion.

ABSTRACT:

Impact statement

Plasmodium falciparum malaria is a global health problem. Erythrocyte invasion by P. falciparum merozoites appears to be a promising target to curb malaria. We have identified and characterized a novel protein that is involved in erythrocyte invasion. Our data on protein subcellular localization, stage-specific protein expression pattern, and merozoite invasion inhibition by α-peptide antibodies suggest a role for PF3D7_1459400 protein during P. falciparum erythrocyte invasion. Even more, the human immunoepidemiology data present PF3D7_1459400 protein as an immunogenic antigen which could be further exploited for the development of new anti-infective therapy against malaria.

SUBMITTER: Amlabu E

PROVIDER: S-EPMC7797990 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Localization and function of a <i>Plasmodium falciparum</i> protein (PF3D7_1459400) during erythrocyte invasion.

Amlabu Emmanuel E Nyarko Prince B PB Opoku Grace G Ibrahim-Dey Damata D Ilani Philip P Mensah-Brown Henrietta H Akporh Grace A GA Akuh Ojo-Ajogu OA Ayugane Evelyn A EA Amoh-Boateng David D Kusi Kwadwo A KA Awandare Gordon A GA

Experimental biology and medicine (Maywood, N.J.) 20201005 1

<h4>Impact statement</h4><i>Plasmodium falciparum</i> malaria is a global health problem. Erythrocyte invasion by <i>P. falciparum</i> merozoites appears to be a promising target to curb malaria. We have identified and characterized a novel protein that is involved in erythrocyte invasion. Our data on protein subcellular localization, stage-specific protein expression pattern, and merozoite invasion inhibition by α-peptide antibodies suggest a role for PF3D7_1459400 protein during <i>P. falcipar ...[more]

PMID: 33019810

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