Pegylated liposomal doxorubicin in patients with epithelial ovarian cancer.

ABSTRACT:

Objective

To evaluate the efficacy and safety of PLD in treating of in patients who experience epithelial ovarian, fallopian tubal, and peritoneal cancer progression within 12 months after the first-line platinum-based therapy.

Methods

This was an open-label, single-arm and multicenter clinical trial. The ORR was the interim primary objective, and the DCR, AEs and QOL were the secondary objectives. The impact of factors on efficacy outcomes, the change trend of CA125 and the artificial platinum-free interval were exploratory endpoints.

Results

Totally, 115 patients were enrolled in this study and included in the ITT population. Moreover, 101 patients were included in the safety population. The median follow-up time was 4 months (IQR 2-6). In the ITT population, the co

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC7798203 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature