Regional brain volume predicts response to methylphenidate treatment in individuals with ADHD.

ABSTRACT:

Background

Despite the effectiveness of methylphenidate for treating ADHD, up to 30% of individuals with ADHD show poor responses to methylphenidate. Neuroimaging biomarkers to predict medication responses remain elusive. This study characterized neuroanatomical features that differentiated between clinically good and poor methylphenidate responders with ADHD.

Methods

Using a naturalistic observation design selected from a larger cohort, we included 79 drug-naive individuals (aged 6-42 years) with ADHD without major psychiatric comorbidity, who had acceptable baseline structural MRI data quality. Based on a retrospective chart review, we defined responders by individuals' responses to at least one-month treatment with methylphenidate. A nonparametric mass-univariate voxel-ba

SUBMITTER: Chang JC 

PROVIDER: S-EPMC7798216 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature