Identification of the active substances and mechanisms of ginger for the treatment of colon cancer based on network pharmacology and molecular docking.

ABSTRACT:

Background and objective

Colon cancer is occurring at an increasing rate and ginger (Zingiber officinale), as a commonly used herbal medicine, has been suggested as a potential agent for colon cancer. This study was aimed to identify the bioactive components and potential mechanisms of ginger for colon cancer prevention by an integrated network pharmacology approach.

Methods

The putative ingredients of ginger and its related targets were discerned from the TCMSP  and Swiss target prediction database. After that, the targets interacting with colon cancer were collected using Genecards, OMIM, and Drugbank databases. KEGG pathway and GO enrichment analysis were performed to explore the signaling pathways related to ginger for colon cancer treatments. The PPI and compound-target

SUBMITTER: Zhang MM 

PROVIDER: S-EPMC7798235 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature