Impact of explicit area scaling on kinetic models involving multiple compartments.

ABSTRACT:

Background

Computational modelling of cell biological processes is a frequently used technique to analyse the underlying mechanisms and to generally understand the behaviour of these processes in the context of a pathway, network or even the whole cell. The most common technique in this context is the usage of ordinary differential equations that describe the kinetics of the relevant processes in mechanistic detail. Here, it is usually assumed that the content of the cell is well-stirred and thus homogeneous - which is of course an over-simplification, but often worked in the past. However, many processes happen at membranes and thus not in 3D, but in 2D. The scaling of the rates of these processes poses a special problem, if volumes of compartments are changed. They will typically

SUBMITTER: Holzheu P 

PROVIDER: S-EPMC7798250 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature