Common variants in MAEA gene contributed the susceptibility to osteoporosis in Han Chinese postmenopausal women.

ABSTRACT:

Background

Osteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblast attacher gene (MAEA) with low bone mineral density in postmenopausal Japanese women. Our study aimed to investigate the association of MAEA with postmenopausal osteoporosis (PMOP) in Han Chinese individuals.

Methods

A total of 968 unrelated postmenopausal Chinese women comprising 484 patients with PMOP and 484 controls were recruited. Four tag single nucleotide polymorphisms (SNPs) that covered the gene region of MAEA were chosen for genotyping. Single SNP and haplotypic association analyses were performed, and analysis of variance was conducted to test the

SUBMITTER: Cai X 

PROVIDER: S-EPMC7798333 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature