Berberine alters gut microbial function through modulation of bile acids.

ABSTRACT:

Background

Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient lipid profiles. Reduction in lipids, particularly cholesterol, is achieved partly through up-regulation of bile acid synthesis and excretion into the gastrointestinal tract (GI). The efficacy of BBR is also thought to be dependent on structural and functional alterations of the gut microbiome. However, knowledge of the effects of BBR on gut microbiome communities is currently lacking. Distinguishing indirect effects of BBR on bacteria through altered bile acid profiles is particularly important in understanding how dietary nutraceuticals alter the microbiome.

Results

Germfree mice were colonized with a define

SUBMITTER: Wolf PG 

PROVIDER: S-EPMC7798349 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature