Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity.

ABSTRACT:

Background

Plasmodium falciparum, the parasite causing malaria, affects populations in many endemic countries threatening mainly individuals with low malaria immunity, especially children. Despite the approval of the first malaria vaccine Mosquirix™ and very promising data using cryopreserved P. falciparum sporozoites (PfSPZ), further research is needed to elucidate the mechanisms of humoral immunity for the development of next-generation vaccines and alternative malaria therapies including antibody therapy. A high prevalence of antibodies against AMA1 in immune individuals has made this antigen one of the major blood-stage vaccine candidates.

Material and methods

Using antibody phage display, an AMA1-specific growth inhibitory human monoclonal antibody from a malaria-immune

SUBMITTER: Seidel-Greven M 

PROVIDER: S-EPMC7798374 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature