Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth.

ABSTRACT: Pseudomonas aeruginosa is an environmental bacterium and an opportunistic human pathogen. It is also a well-established model organism to study bacterial adaptation to stressful conditions, such as those encountered during an infection process in the human host. Advancing knowledge on P. aeruginosa adaptation to biofilm growth conditions is bound to reveal novel strategies and targets for the treatment of chronic biofilm-associated infections. Here, we generated transposon insertion libraries in three P. aeruginosa strain backgrounds and determined the relative frequency of each insertion following biofilm growth using transposon sequencing. We demonstrate that in general the SOS response, several tRNA modifying enzymes as well as adaptation to microaerophilic growth c

SUBMITTER: Schinner S 

PROVIDER: S-EPMC7798452 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature