The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth.

ABSTRACT: Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical genes remains elusive. The goal of the present study is to elucidate the role of small proteins in B. cenocepacia, focusing on genes smaller than 300 base pairs of which the function is unknown. Almost 10% (572) of the B. cenocepacia J2315 genes are smaller than 300 base pairs and more than half of these are annotated as coding for hypothetical proteins. For 234 of them no similarity could be found with non-hypothetical genes in other bacteria using BLAST. Using available RNA sequencing data obtained from biofilms, a

SUBMITTER: Van Acker H 

PROVIDER: S-EPMC7798474 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature