Surface functionalization-dependent localization and affinity of SiO₂ nanoparticles within the biofilm EPS matrix.

ABSTRACT: The contribution of the biofilm extracellular polymeric substance (EPS) matrix to reduced antimicrobial susceptibility in biofilms is widely recognised. As such, the direct targeting of the EPS matrix is a promising biofilm control strategy that allows for the disruption of the matrix, thereby allowing a subsequent increase in susceptibility to antimicrobial agents. To this end, surface-functionalized nanoparticles (NPs) have received considerable attention. However, the fundamental understanding of the interactions occurring between engineered NPs and the biofilm EPS matrix has not yet been fully elucidated. An insight into the underlying mechanisms involved when a NP interacts with the EPS matrix will aid in the design of more efficient NPs for biofilm control. Here we demonstrate the us

SUBMITTER: Hiebner DW 

PROVIDER: S-EPMC7798476 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature