Silk derived formulations for accelerated wound healing in diabetic mice.

ABSTRACT:

Background

The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice.

Methods

Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis.

Results

The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound con

SUBMITTER: Tariq M 

PROVIDER: S-EPMC7798629 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature