Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants.

ABSTRACT:

Background

Human spillovers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to dogs and the emergence of a highly contagious avian-origin H3N2 canine influenza virus have raised concerns on the role of dogs in the spread of SARS-CoV-2 and their susceptibility to existing human and avian influenza viruses, which might result in further reassortment.

Methods

We systematically studied the replication kinetics of SARS-CoV-2, SARS-CoV, influenza A viruses of H1, H3, H5, H7, and H9 subtypes, and influenza B viruses of Yamagata-like and Victoria-like lineages in ex vivo canine nasal cavity, soft palate, trachea, and lung tissue explant cultures and examined ACE2 and sialic acid (SA) receptor distribution in these tissues.

Results

There was limited productive

SUBMITTER: Bui CHT 

PROVIDER: S-EPMC7799041 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature