The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies.

ABSTRACT: SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has posed a worldwide challenge to human health as no effective treatment is currently available to combat the disease. Its severity has led to unprecedented collaborative initiatives for therapeutic solutions against COVID-19. Studies resorting to structure-based drug design for COVID-19 are plethoric and show good promise. Structural biology provides key insights into 3D structures, critical residues/mutations in SARS-CoV-2 proteins, implicated in infectivity, molecular recognition and susceptibility to a broad range of host species. The detailed understanding of viral proteins and their complexes with host receptors and candidate epitope/lead compounds is the key to developing a structure-guided therapeutic d

SUBMITTER: Waman VP 

PROVIDER: S-EPMC7799268 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature