Improvement of islet transplantation by the fusion of islet cells with functional blood vessels.

ABSTRACT: Pancreatic islet transplantation still represents a promising therapeutic strategy for curative treatment of type 1 diabetes mellitus. However, a limited number of organ donors and insufficient vascularization with islet engraftment failure restrict the successful transfer of this approach into clinical practice. To overcome these problems, we herein introduce a novel strategy for the generation of prevascularized islet organoids by the fusion of pancreatic islet cells with functional native microvessels. These insulin-secreting organoids exhibit a significantly higher angiogenic activity compared to freshly isolated islets, cultured islets, and non-prevascularized islet organoids. This is caused by paracrine signaling between the β-cells and the microvessels, mediated by insulin binding t

SUBMITTER: Nalbach L 

PROVIDER: S-EPMC7799357 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature