Local and global consequences of reward-evoked striatal dopamine release.

ABSTRACT: The neurotransmitter dopamine is required for the reinforcement of actions by rewarding stimuli¹. Neuroscientists have tried to define the functions of dopamine in concise conceptual terms², but the practical implications of dopamine release depend on its diverse brain-wide consequences. Although molecular and cellular effects of dopaminergic signalling have been extensively studied³, the effects of dopamine on larger-scale neural activity profiles are less well-understood. Here we combine dynamic dopamine-sensitive molecular imaging⁴ and functional magnetic resonance imaging to determine how striatal dopamine release shapes local and global responses to rewarding stimulation in rat brains. We find that dopamine consistently alters the duration,

SUBMITTER: Li N 

PROVIDER: S-EPMC7799633 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature