Reno-protective effect of IL-34 inhibition on cisplatin-induced nephrotoxicity in mice.

ABSTRACT:

Introduction

Interleukin-34 (IL-34) shares a receptor (cFMS) with colony stimulating factor-1 (CSF-1), and these two ligands mediate macrophage proliferation. However, in contrast to CSF-1, the influence of IL-34 on tubular epithelial cells (TECs) injury remains unclear. We investigated the physiological effects of IL-34 on TEC damage caused by cisplatin nephrotoxicity (CP-N).

Methods

Mice were administered anti-mouse IL-34 antibody (anti-IL-34 Ab; 400 ng/kg) or vehicle from 1 day before and up to 2 days after CP-N induction. In vitro, mouse renal proximal TECs (MRPTEpiC) were cultured to analyze the inhibitory effects of IL-34 on CP-induced TEC apoptosis.

Results

Compared to vehicle treatment, anti-IL-34 Ab treatment significantly suppressed the intra-renal expressio

SUBMITTER: Wada Y 

PROVIDER: S-EPMC7799787 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature