Data-Driven Discovery of Molecular Targets for Antibody-Drug Conjugates in Cancer Treatment.

ABSTRACT: Antibody-drug conjugate therapy has attracted considerable attention in recent years. Since the selection of appropriate targets is a critical aspect of antibody-drug conjugate research and development, a big data research for discovery of candidate targets per tumor type is outstanding and of high interest. Thus, the purpose of this study was to identify and prioritize candidate antibody-drug conjugate targets with translational potential across common types of cancer by mining the Human Protein Atlas, as a unique big data resource. To perform a multifaceted screening process, XML and TSV files including immunohistochemistry expression data for 45 normal tissues and 20 tumor types were downloaded from the Human Protein Atlas website. For genes without high protein expression across critic

SUBMITTER: Razzaghdoust A 

PROVIDER: S-EPMC7801065 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature