Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke.

ABSTRACT: Chemokine (C-C motif) receptor 5 (CCR5) is expressed not only in the immune cells but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high expression of CCR5 in the brain. However, the role of CCR5 in stroke remains unclear. In this study, using bone marrow chimeras we have determined the involvement of brain-derived or bone marrow-derived CCR5 in neuroprotection and brain repair after experimental stroke. CCR5^-/- mice that received either wild-type (WT) or CCR5^-/- bone marrow transplantation showed larger infarction sizes than the WT mice that received either WT or CCR5^-/- bone marrow transplantation in both the acute (48h) and subacute (2 months) phases after cerebral cortical ischemia, suggesting that the lack of CCR5 in

SUBMITTER: Ping S 

PROVIDER: S-EPMC7801286 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature