Evaluating the efficacy of treatment options for anal intraepithelial neoplasia: a systematic review.

ABSTRACT:

Purpose

Anal intraepithelial neoplasia (AIN) is the accepted precursor of anal squamous cell carcinoma (ASCC). There has long been a hypothesis that treating AIN may prevent ASCC. Many different treatment modalities have been suggested and studied. We conducted this systematic review to evaluate their efficacy and the evidence as to whether we can prevent ASCC by treating AIN.

Methods

MEDLINE and EMBASE were electronically searched using relevant search terms. All studies investigating the use of a single treatment for AIN that reported at least one end outcome such as partial or complete response to treatment, recurrence after treatment and/or ASCC diagnosis after treatment were included.

Results

Thirty studies were included in the systematic review investigating 10

SUBMITTER: Brogden DRL 

PROVIDER: S-EPMC7801290 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature