Anti-Mullerian hormone levels and risk of type 2 diabetes in women.

ABSTRACT:

Aims/hypothesis

Given its role in ovarian follicle development, circulating anti-Müllerian hormone (AMH) is considered to be a marker of reproductive ageing. Although accelerated reproductive ageing has been associated with a higher risk of type 2 diabetes, research on the relationship between AMH and type 2 diabetes risk is scarce. Therefore, we aimed to investigate whether age-specific AMH levels and age-related AMH trajectories are associated with type 2 diabetes risk in women.

Methods

We measured AMH in repeated plasma samples from 3293 female participants (12,460 samples in total), aged 20-59 years at recruitment, from the Doetinchem Cohort Study, a longitudinal study with follow-up visits every 5 years. We calculated age-specific AMH tertiles at baseline to account for

SUBMITTER: Verdiesen RMG 

PROVIDER: S-EPMC7801305 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature