DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples.

ABSTRACT:

Purpose

Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for early detection of CRC and could be detected in more than one type of material from the patient. We systematically reviewed the literature on DNA methylation markers of colorectal cancer, detected in more than one type of material, regarding their potential as contributors to a panel for screening and follow-up of CRC.

Methods

The databases MEDLINE, Web of Science, and Embase were systematically searched. Data extraction and review was performed by two authors independently. Agreement between methylation status in tissue and other materials (blood/stool/urine) was analyzed using the McNemar test

SUBMITTER: Laugsand EA 

PROVIDER: S-EPMC7801356 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature