Depression as a risk factor for dementia in older people with type 2 diabetes and the mediating effect of inflammation.

ABSTRACT:

Aims/hypothesis

We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship.

Methods

The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-75 years. Cox proportional hazards regression analysis was used to investigate the association between depression, assessed at baseline, and subsequent risk of dementia over 10 years. Depression was defined using the Hospital Anxiety and Depression Scale, while incident dementia was defined using medical records, prescription data and death certificates. The potential mediating effect of systemic inflammation was assessed by adjusting models for a generalised in

SUBMITTER: Carr AL 

PROVIDER: S-EPMC7801357 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature