FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro.

ABSTRACT:

Introduction

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase protein frequently overexpressed in cancer and has been linked to an increase in the stem cell population of tumors, resistance to therapy, and metastatic spread. Pharmacological FAK inhibition in pancreatic cancer has received increased attention over the last few years, either alone or in combination with other therapeutics including chemotherapy and immunotherapy. However, its prognostic value and its role in radioresistance of pancreatic ducal adenocarcinoma (PDAC) is unknown.

Methods and materials

Using the TCGA and GTEx databases, we investigated the genetic alterations and mRNA expression levels of PTK2 (the encoding-gene for FAK) in normal pancreatic tissue and pancreatic cancer and its impact

SUBMITTER: Mohamed AA 

PROVIDER: S-EPMC7801360 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature