Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity.

ABSTRACT:

Aims/hypothesis

Mitochondria operate in networks, adapting to external stresses and changes in cellular metabolic demand and are subject to various quality control mechanisms. On the basis of these traits, we here hypothesise that the regulation of mitochondrial networks in skeletal muscle is hampered in humans with compromised oxidative capacity and insulin sensitivity.

Methods

In a cross-sectional design, we compared four groups of participants (selected from previous studies) ranging in aerobic capacity and insulin sensitivity, i.e. participants with type 2 diabetes (n = 11), obese participants without diabetes (n = 12), lean individuals (n = 10) and endurance-trained athletes (n = 12); basal, overnight fasted muscle biopsies were newly analysed for the current study and

SUBMITTER: Houzelle A 

PROVIDER: S-EPMC7801361 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature