Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio).

ABSTRACT: Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in multiple age-related diseases and is associated with chronic activation of the hypothalamus-pituitary-adrenal (HPA) axis, providing a link between stress-related personality differences and adverse health outcomes. However, the effects of the HPA axis are tissue specific. Thus, leukocyte telomere length may not accurately reflect telomere length in disease-relevant tissues. Here, we examined the correlation between stress reactivity and telomere length in heart and brain tissue in young (6-9 month) and aging

SUBMITTER: Evans JR 

PROVIDER: S-EPMC7801459 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature