CREPT is required for murine stem cell maintenance during intestinal regeneration.

ABSTRACT: Intestinal stem cells (ISCs) residing in the crypts are critical for the continual self-renewal and rapid recovery of the intestinal epithelium. The regulatory mechanism of ISCs is not fully understood. Here we report that CREPT, a recently identified tumor-promoting protein, is required for the maintenance of murine ISCs. CREPT is preferably expressed in the crypts but not in the villi. Deletion of CREPT in the intestinal epithelium of mice (Vil-CREPT^KO) results in lower body weight and slow migration of epithelial cells in the intestine. Vil-CREPT^KO intestine fails to regenerate after X-ray irradiation and dextran sulfate sodium (DSS) treatment. Accordingly, the deletion of CREPT decreases the expression of genes related to the proliferation and differentiation of I

SUBMITTER: Yang L 

PROVIDER: S-EPMC7801528 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature