Spatial modeling of biological patterns shows multiscale organization of Arabidopsis thaliana heterochromatin.

ABSTRACT: The spatial organization in the cell nucleus is tightly linked to genome functions such as gene regulation. Similarly, specific spatial arrangements of biological components such as macromolecular complexes, organelles and cells are involved in many biological functions. Spatial interactions among elementary components of biological systems define their relative positioning and are key determinants of spatial patterns. However, biological variability and the lack of appropriate spatial statistical methods and models limit our current ability to analyze these interactions. Here, we developed a framework to dissect spatial interactions and organization principles by combining unbiased statistical tests, multiple spatial descriptors and new spatial models. We used plant constitutive heterochr

SUBMITTER: Arpon J 

PROVIDER: S-EPMC7801681 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature